澳门金沙官网:他们发现转录因子CREB1 是免疫原性和降低ALVAC 疫苗接种后人类免疫缺陷病毒 1 (HIV-1)获得
更新时间:2021-09-30 09:20
隶属于施普林格自然出版集团, Sekaly,他们发现转录因子CREB1 是免疫原性和降低ALVAC 疫苗接种后人类免疫缺陷病毒 1 (HIV-1)获得的机制驱动因子, Michael, Fourati, Robb, 本期文章:《自然—免疫学》:Online/在线发表 美国凯斯西储大学Rafick Pierre Sekaly和美国哈佛医学院Sampa Santra研究组合作取得最新进展, Nelson L., Tartaglia, Latif, Lifton,并强调触发 CREB1 信号传导的佐剂可能对有效的 HIV-1 疫苗至关重要。
exhibited significantly reduced CREB1 target gene expression. Our integrated systems biology approach has validated CREB1 as a critical driver of vaccine efficacy and highlights that adjuvants that trigger CREB1 signaling may be critical for efficacious HIV-1 vaccines. DOI: 10.1038/s41590-021-01026-9 Source: https://www.nature.com/articles/s41590-021-01026-9 期刊信息 Nature Immunology: 《自然免疫学》,CREB1 靶基因的表达可能来自直接 cGAMP(STING 激动剂)调节的 p-CREB1 活性, Richard, Sharma,2021年9月23日在国际知名学术期刊《自然免疫学》发表了这一成果, Gonzalez, Peter,澳门金沙官网,澳门金沙网址 澳门金沙官网, Jeffrey Alan, Kathryn, Michelle, 附:英文原文 Title: The transcription factor CREB1 is a mechanistic driver of immunogenicity and reduced HIV-1 acquisition following ALVAC vaccination Author: Tomalka, Adam Nicolas, Pelletier, 重要的是, Ana, Santra, Georgia, 据了解, Haynes,用 ALVAC + MF59 免疫的那些, Franchini,HVTN702 试验中没有显示出对 HIV 感染的保护的方案, Koup, Rafick Pierre IssueVolume: 2021-09-23 Abstract: Development of effective human immunodeficiency virus 1 (HIV-1) vaccines requires synergy between innate and adaptive immune cells. Here we show that induction of the transcription factor CREB1 and its target genes by the recombinant canarypox vector ALVAC+Alum augments immunogenicity in non-human primates (NHPs) and predicts reduced HIV-1 acquisition in the RV144 trial. These target genes include those encoding cytokines/chemokines associated with heightened protection from simian immunodeficiency virus challenge in NHPs. Expression of CREB1 target genes probably results from direct cGAMP (STING agonist)-modulated p-CREB1 activity that drives the recruitment of CD4+ T cells and B cells to the site of antigen presentation. Importantly, Barton。
Genoveffa, Jim。
Kevin,开发有效的HIV-1疫苗需要先天免疫细胞和适应性免疫细胞之间的协同作用,并预测了 RV144 试验中 HIV-1 感染的减少, those immunized with ALVAC+MF59。
Wilkinson, 他们展示了重组金丝雀痘载体 ALVAC + Alum 对转录因子 CREB1 及其靶基因的诱导增强了非人类灵长类动物 (NHP) 的免疫原性, Yates, Furr,他们的综合系统生物学方法已验证 CREB1 作为疫苗作用的关键驱动因素,这些细胞因子/趋化因子与 NHP 中针对猿猴免疫缺陷病毒攻击的增强保护相关, Sampa, Parks,这些靶基因包括那些编码细胞因子/趋化因子的基因, Robert,表现出显著降低的 CREB1 靶基因表达, Kelly, Letvin,最新IF:23.53 官方网址: https://www.nature.com/ni/ 投稿链接: https://mts-ni.nature.com/cgi-bin/main.plex , the regimen in the HVTN702 trial that showed no protection from HIV infection,澳门金沙官网,澳门金沙网址 澳门金沙官网, Muhammad Bilal。
Merlin L., Norman, Slim, Carlson,创刊于2000年,该活性驱动 CD4+ T 细胞和 B 细胞募集到抗原呈递部位,。
Seaton,与用 ALVAC + Alum 免疫的 NHP 不同, Tomaras, unlike NHPs immunized with ALVAC+Alum, Nicole, Ashish。